Dimethecaine (MDPV)

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Description

Dimethocaine is a local anesthetic and a stimulant that has some cocaine-like activity. It’s generally reported to be weaker than cocaine and amphetamine. Dimethocaine, dimethocaine synthesis, dimethocaine australia

A minimal amount of recreational use has been reported since the late 2000s.

The substance was previously used in the 1930s as an anesthetic.


Dimethocaine = Larocaine; 94-15-5

PubChem: 7177

Molecular formula: C16H26N2O2

Molecular weight: 278.396 g/mol

IUPAC: [3-(diethylamino)-2,2-dimethylpropyl] 4-aminobenzoate

Dose of Dimethocaine

Intranasal (tentative)

  • Range: 50 – 200 mg

Timeline

Intranasal (tentative)

  • Total: 2 – 4 hours
  • Onset: 00:10 – 00:20

IV (tentative)

  • Total: 10 – 30 minutes
  • Onset: Within seconds

Effects of Dimethocaine

Positive

  • Euphoria
  • Stimulation
  • Increased talkativeness
  • Mood lift

Negative

  • Tachycardia
  • Difficulty breathing
  • Chest pain
  • Vasoconstriction
  • Insomnia
  • Paranoia
  • Anxiety

There are a limited number of reports about the drug’s effects. Most point to little activity or, at most, mild euphoria and mild stimulation.

Stimulation and euphoria offered by the drug are generally said to be weaker than what’s offered by cocaine or amphetamine.

The local anesthetic effect generally leads to numbness in the nasal region when taken intranasally.

Some users have experienced fatigue and slight mental impairment when the effects dissipate and even a lasting CNS depressant effect the following day. However, the lack of experience reports makes it difficult to tell how common these after-effects are.

Animal studies

It had a memory impairing effect in mice in a maze test. This was hypothesized in the paper to come from a dopamine mechanism. Lidocaine, which lacks similar dopaminergic activity, didn’t have the same response.

Greater locomotor activity and cocaine-like behavior effects in mice.

Anxiogenic effects were seen at 10 mg/kg and 20 mg/kg in a maze test in mice.

Dimethocaine had some apparent dose-dependent antinociceptive effects in mice, including in writhing and hot-plate tests.

Safety For Dimethocaine

We don’t have enough information to know how safe the drug is, especially with long-term use. It’s wise to use the lowest possible dose as infrequently as possible and without combinations.

Lethal dose

LD50 values

Mouse (subcutaneous): 300 mg/kg (potential human equivalent of 24 mg/kg)

Rabbit (subcutaneous): 150 mg/kg (potential human equivalent of 49 mg/kg)


Cardiotoxicity is a concern with the substance and it’s possible the drug poses similar (or greater) risks to cocaine.


Risky Combinations (list may not be complete)

Other stimulants, MAOIs, and tramadol.

Additional information

Quantity

10g, 25g, 50g, 100g, 500g